Molecular Mechanisms of Mouse Skin Tumor Promotion
نویسندگان
چکیده
منابع مشابه
Molecular Mechanisms of Mouse Skin Tumor Promotion
Multiple molecular mechanisms are involved in the promotion of skin carcinogenesis. Induction of sustained proliferation and epidermal hyperplasia by direct activation of mitotic signaling pathways or indirectly in response to chronic wounding and/or inflammation, or due to a block in terminal differentiation or resistance to apoptosis is necessary to allow clonal expansion of initiated cells w...
متن کاملMouse skin tumor initiation-promotion and complete carcinogenesis bioassays: mechanisms and biological activities of emission samples.
Extracts of soots obtained from various sources were applied to the skin of mice in an effort to identify carcinogens in these mixtures and to link these materials to the etiology of human cancer. Samples of coal chimney soot, coke oven materials, industrial carbon black, oil shale soot, and gasoline vehicle exhaust materials have been examined by this method. The studies reported here have bee...
متن کاملInhibition of multistage tumor promotion in mouse skin by diethyldithiocarbamate.
Diethyldithiocarbamate (DDTC) injected i.p. inhibits remarkably and in a dose-dependent manner 12-O-tetradecanoylphorbol-13-acetate (TPA)-decreased glutathione (GSH) peroxidase and TPA-induced ornithine decarboxylase (ODC) activities in mouse epidermis in vivo. DDTC is more potent in inhibiting these effects of TPA than 16 other antioxidants, free radical scavengers, thiol-containing compounds,...
متن کاملMechanism of Mouse Skin Tumor Promotion by Chrysarobin1
The skin tumor-promoting ability of 1,8-dihydroxy-3-methyl-9anthrone (chrysarobin) was compared with that of 12-O-tetradecanoylphorbol-13-acetate(TPA)and 1,8-dihydroxy-9-anthrone (anthralin) in SENCAR mice. Although dose-response compari sons indicated that chrysarobin was several orders of magnitude less potent than TPA for promoting papilloma formation, this anthrone was 1.5 to 2 times more p...
متن کاملMechanism of mouse skin tumor promotion by chrysarobin.
The skin tumor-promoting ability of 1,8-dihydroxy-3-methyl-9-anthrone (chrysarobin) was compared with that of 12-O-tetradecanoylphorbol-13-acetate (TPA) and 1,8-dihydroxy-9-anthrone (anthralin) in SENCAR mice. Although dose-response comparisons indicated that chrysarobin was several orders of magnitude less potent than TPA for promoting papilloma formation, this anthrone was 1.5 to 2 times more...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cancers
سال: 2010
ISSN: 2072-6694
DOI: 10.3390/cancers2020436